منابع مشابه
Imaging of Neuro-Inflammation
Vasogenic edema is associated with BBB dysfunction, which allows an increase in the passage of plasma proteins and water into the extracellular compartment [3, 5]. This is the main type of edema associated with inflammation and will be the main focus of this thesis. In hydrocephalus, a rise in intraventricular pressure causes the cerebro-spinal fluid (CSF) to migrate through the ependyma into t...
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Neuro-inflammation is a reaction to brain injury involving the activation of glial cells and release of inflammatory mediators, such as cytokines and chemokines which has a key role in neuro-degenerative diseases. Periodontitis is a microbiome-related dental inflammation caused by gram- negative bacteria that leads to connective tissue destruction and loss of teeth. Previous studies demonstrated...
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Treating Central Nervous System (CNS) neuro-inflammational disorders is of great importance. A key aspect of this treatment includes regulation of Cell-Mediated and humoral immune systems. Previous treatment mostly consisted of systemic immunosuppressive drugs. In addition to having adverse side effects, these drugs were also inefficient, such as methotrexate- Cyclophosphamide-Azathioprine. Rec...
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Neuro-inflammation is a pivotal physio-pathological feature of brain disorders, including neurodegenerative diseases. As such, it is a relevant therapeutic target against which drugs have to be proposed. Targeting neuro-inflammation implies crossing the Blood-Brain Barrier (BBB) to reach the Central Nervous System (CNS). Engineered nanoparticles (ENPs) are promising candidates to carry and deli...
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The topical application of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) to murine skin produces acute inflammatory and hyperplastic responses that have been associated with the promotion stage of skin carcinogenesis. It has been shown in a previous study that TPA induces the expression of the highly inflammatory cytokine, interleukin (IL) -la, in the epidermis of SENCAR mice. T...
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ژورنال
عنوان ژورنال: médecine/sciences
سال: 2015
ISSN: 0767-0974,1958-5381
DOI: 10.1051/medsci/20153111012